Endocrine Abstracts

Introduction: Female sexual dysfunctions (FSD) are complex conditions characterized by impairment of the female sexual cycle. Higher prevalence of FSD has been found in women with diabetes, as compared with matched healthy controls. Endothelial progenitor cells (EPCs) are circulating mononuclear cells participating in the neo-angiogenesis. There is evidence that circulating levels of EPCs are reduced in diabetic patients compared with age-matched subjects. The relationship bet...

: A link between thyroid dysfunction and diabetes mellitus exist. Uncertainties on the role of glycemic variability on thyroid hormones and TSH concentrations still persist. We want to evaluate the influence of glycemic variability on thyroid hormones and TSH concentrations in patients with type 1 diabetes (T1DM). 77 patients with T1DM on insulin therapy without thyroid dysfunction and 100 healthy controls were evaluated for basal glucose concentrations, HbA1c, thyroid hormone...

Diurnal salivary and plasma cortisol variations are considered valid expression of circadian cortisol rhythmicity. The aim of this study was to assess the reliability of salivary and plasma cortisol evaluating if glycemia and glycemic oscillations may interfere with their concentration.Methods: Forty-seven type 2 diabetic patients and 31 controls were studied for glycemic profile and diurnal salivary and plasma cortisol variations on two contemporary sam...

Hypothyroidism therapy is based on the administration of appropriate dose of L-thyroxine (L-T4). Absorption of L-T4 takes place in the duodenum and upper tract of the small intestine (jejunum), is maximal when stomach is empty, and is affected by a number of gastrointestinal disorders, including Helicobacter pylori–related gastritis, as well as ingestion of drugs, dietary fibers, and herbal remedies. Failure to achieve a good control of disease may be due to malabsorption...

Objective: Our institution (University Hospital “L. Vanvitelli“ - Naples, Italy) is a high-volume (HV) center in Naples metropolitan area and many patients are referred there to repeat thyroid fine-needle aspiration cytology (FNAC) after initial FNAC performed in low-volume institutions (LV). The aims of the study were to 1) to examine the inter-observer agreement between HV and LV institutions according to the Italian thyroid cytology system, and 2) explore how the ...

Context: Women with autoimmune Addison’s disease with normally ovulatory cycles but positive for steroid cells antibodies (StCA) have been considered at risk of premature ovarian insufficiency (POI).Design: Thirty-three women younger than 40 years, with subclinical-clinical Addison’s disease but with normally ovulatory menses, were followed-up for 10 years to evaluate the long-term time-related variations of StCA, ovarian function and follicula...

Objective: Since the relationship between thymic hyperplasia (TH) and Graves’ Disease (GD) is of paramount importance for diagnostic and therapeutic choices, a wider knowledge of this association is required for endocrinologists in routine clinical practice. Our aim was to assess the prevalence, the clinical features, and the response to treatment of GD-related TH in an Academic referral centre.Methods: All consecutive cases of GD-related TH at Univ...

Background and aim: Obesity is associated with a dysregulation of the immune system which can result in a predisposition to the development of autoimmune diseases. The aim of this cross-sectional study was to evaluate anti-pituitary antibodies (APA) in severe obese patients, in order to identify a possible role of the immune system in obesity and to correlate these antibodies with pituitary hormone changes found in obese patients.Matherials and methods: ...